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FREQUENTLY ASKED QUESTIONS
IBOGAINE AFFECTS THE CIRCULATORY SYSTEM IN ADDITION TO HAVING NEUROTOXIC EFFECTS (E.G., [2,5,18,19,20]). IN RECENT YEARS, WORRISOME REPORTS OF CASES OF SUDDEN DEATH AND LIFE-THREATENING COMPLICATIONS THAT OCCURRED CONCURRENTLY WITH THE ADMINISTRATION OF THE ALKALOID HAVE BEEN ACCUMULATING.
IBOGAINE IS AN INDOLE ALKALOID THAT CAN BE PRODUCED BY EITHER EXTRACTING IT FROM THE IBOGA PLANT OR SEMI-SYNTHESIZING IT USING THE PLANT ALKALOID VOACANGINE AS A PRECURSOR.
Tribal cultures place a high value on ibogaine. Ibogaine reduces hunger, thirst, and fatigue when used in small doses. However, at larger doses, it might result in intense visuals.
Ibogaine binds to the cocaine site of the serotonin transporter and inhibits the absorption of both dopamine and serotonin. It stops the rise in brain serotonin levels brought on by cocaine. Additionally, ibogaine inhibits the release of dopamine brought on by cocaine, morphine, and nicotine.
IBOGAINE MAY BE ABLE TO REVERSE THE EFFECTS OF OPIATES ON GENE EXPRESSION, WHICH WOULD HAVE AN IMPACT ON NEURORECEPTORS AND RESTORE THEM TO THEIR PRE-ADDICTION STATE (BRACKENRIDGE, 2010). ADDITIONALLY, THE BRAIN’S ADDICTIVE LOOPS AND PATHWAYS ARE CHANGED (HE ET AL., 2005).